Did you know major depressive disorder is one of the most common mental disorders in the United States?

Almost 7% of the U.S. population is diagnosed with depression. Tweet >

Clinical depression is a serious condition that negatively affects how a person thinks, feels, and behaves. In contrast to normal sadness, clinical depression is persistent, and significantly interferes with daily life. Untreated, symptoms can last for weeks, months, or years; and if inadequately treated, depression can lead to other health-related issues. Symptoms include: a depressed mood most of the day, every day; diminished interest in daily activities; changes in appetite and sleeping patterns; fatigue; restlessness; anxiety; feelings of worthlessness or helplessness; difficulty concentrating; increased alcohol or drug use; thoughts of death or suicide.

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Paul Greengard, Ph.D. - Brain & Behavior Research Expert on Depression
Paul Greengard, Ph.D.
November 13, 2015
Blocking a receptor in the brain called mGluR5 is considered a potential strategy for treating a number of disorders, including major depression, Parkinson’s...
Monsheel Sodhi, Ph.D. - Brain & behavior research expert on suicide and depression
Monsheel Sodhi, Ph.D.
October 27, 2015
Researchers have found patterns of gene activity linked to depression and the likelihood of  death by suicide that differ between men and women. Looking at...
Alexandre G. Dayer, M.D. - Brain & Behavior Research Expert on Depression
Alexandre G. Dayer, M.D.
October 20, 2015
In a study of mice, researchers have found that the positioning of brain cells is affected by early-life impairment of the system that regulates serotonin — a...
Yvette I. Sheline, M.D. - Brain & Behavior Research Expert on PTSD
Yvette I. Sheline, M.D.
October 16, 2015
Anxiety and depression symptoms in major depression and post-traumatic stress disorder reflect abnormal connections to the same emotion center in the brain,...
Steven J. Siegel, M.D., Ph.D. - Brain & Behavior Research Expert on Depression
Steven J. Siegel, M.D., Ph.D.
October 13, 2015
Ketamine, an anesthetic that is being tested as a fast-acting antidepressant, causes delayed social development and changes in brain function that last into...


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