NARSAD Independent Investigator Madhukar H. Trivedi, MD and colleagues have discovered that various forms of exercise worked as effectively as adding a second antidepressant medication.

The 4-year controlled study involved patients performing various forms of exercise, journaling and meeting regularly with a psychiatrist. The results demonstrated that medication combined with a regular exercise routine fully relieved the symptoms of major depressive disorder for up to 50% of patients requiring more than one antidepressant.

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