Research News Update – New View of Depression
Research News Update – New View of Depression
Two-time NARSAD Grant recipient Owen M. Wolkowitz, M.D. is one of the researchers responsible for the work profiled. His second NARSAD Grant initiated studies of "Neuroendocrinology of depression and psychosis" and that research provided the background for the currently reported analysis. The article consults with P. Murali Doraiswamy, M.D., of Duke University, whose NARSAD Grant-funded research focused on cerebral drug flow measurement in late life depression.
In an effort to study accelerated aging on a cellular level, researchers are focusing on telomeres, a protective covering at the ends of chromosomes which have been recognized as playing an important role in aging. Researchers know that as people get older, telomeres get shorter and that shortened telomeres are linked to increased risk of disease and death. Other studies have shown that shortened telomeres are associated with depression, childhood trauma and other conditions. Dr. Doraiswamy, head of the division of biological psychiatry at Duke University, says that “The ‘holy grail’ of this area of work is to try to find the molecular mechanisms by which depression or stress take their toll on the body. Such information could help provide clues about how much of age-related disease is due to genetics versus life experience, and whether it can be reversed.”
In the progressive way that research works, future studies will be focused on determining how severe a psychological experience must be to affect telomere length and what can be done to prevent and/or effectively treat the condition.