With the help of an initial NARSAD Distinguished Investigator grant, Randy Blakely, Ph.D., and a team of researchers at Vanderbilt University and the University of Texas Health Sciences Center in San Antonio have developed a new mouse model that will test the theory of how SSRIs work and could lead to the development of entirely new treatments for depression.

These mice, described in the online edition of the Proceedings of the National Academy of Sciences (PNAS), express a serotonin transporter that has been genetically altered so that it does not respond to many SSRIs or cocaine.

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