treatment-resistant depression

Direct Evidence of Ketamine’s Antidepressant Action in Imaging Study of Excitatory Neuronal Receptors
A team of researchers has published results of experiments in patients with treatment-resistant depression that provides direct evidence of at least one important mechanism through which ketamine… Read More
Novel Target in Dopamine Neurons is Basis of Potential New Therapeutic Approach for Treatment-Resistant Depression
Even with the development and FDA approval in recent years of the first rapid-acting antidepressant medicines—to which more than 90 BBRF grants have contributed—the search for novel depression… Read More
“Still Depressed” or “Recovering”? Researchers Find Biomarker Signaling Recovery in Treatments for Severe Depression Using Deep Brain Stimulation
Researchers say they have identified an objective biomarker of recovery in major depression that in a small cohort of treatment-resistant patients was able (on an ongoing basis) to capture whether… Read More
Talk Therapy + Brain Stimulation Reduced Suicidal Ideation in Patients with Borderline Personality Disorder and Treatment-Resistant Depression, Pilot Trial Shows
About 1.4% of U.S. adults (over 3 million people) experience Borderline Personality Disorder (BPD) in a typical year. But BPD is difficult to treat. Evidence for the effectiveness of medications… Read More
Non-Invasive Brain-Stimulation Protocol for Treatment-Resistant Depression Enabled 79% to Experience Remission Following 5-Day Treatment Course
In its first randomized, placebo-controlled test, an enhanced form of non-invasive brain stimulation called SNT (Stanford Neuromodulation Therapy, formerly called SAINT) generated "a large… Read More