antidepressants

Patterns of Early Changes in Brain’s Functional Connectivity in Response to SSRI Antidepressants and Placebo Could Aid Precision Psychiatry
In a comprehensive study of data from 386 patients with major depressive disorder (MDD), researchers have characterized changes in functional connectivity in the brain during the first 2 weeks after… Read More
Predictive Biomarkers Tested in Clinical Trial Corresponded With 66% Improvement in Antidepressant Response Rate
Considerable effort has been made to identify bio-behavioral markers—neural, behavioral, and clinical variables—that will predict whether a depressed person will respond or fail to respond to… Read More
Experiments That May Answer the Riddle of Ketamine’s Rapid Antidepressant Action Are Basis for Finding Other Rapid-Acting Treatments With Fewer Side Effects
In a what could be a major step forward in depression research, a team led by BBRF grantees has reported the results of experiments that they say reveals the mechanism through which the rapid anti… Read More
Over the Long Term, Antipsychotic Medicine Stabilized Functional Connectivity in Depressed Patients with Psychosis
Psychosis, which involves hallucinations, delusions, and other distortions of thought and perception, is often associated with schizophrenia. But it also occurs in other disorders, including major… Read More
Lumateperone, an Antipsychotic, is Tested in a Phase 3 Trial for Major Depressive Episodes in Bipolar I and II Disorders
An international team of researchers has reported positive results in a phase 3 clinical trial of a drug to treat depressive episodes in patients with bipolar I and bipolar II disorder. Read More