Fear

Researchers Propose Fear and Anxiety Are Generated by Separate Brain Circuits

Fear and anxiety are often described as primal responses to danger, with their emotional and physiological components triggered by a single fear circuit in the brain. But in the September 9 issue of… Read More

Doubt is Cast on the Contribution of Older Fathers' Gene Mutations to Increased Mental Illness Risk in Their Children

Children born to older fathers have a higher risk of developing mental illnesses such as schizophrenia and autism spectrum disorders. Now, a new study suggests that age-related genetic mutations… Read More

In PTSD, Brain Overreacts to Cues Not Directly Linked to Negative Experiences

TAKEAWAY: Researchers have identified a molecular pathway in a specific neural connection in the brain that is disrupted in patients with 22q11 deletion syndrome, a genetic error that is associated with schizophrenia. The pathway, which relies on a microRNA called miR-338-3p, is involved in neural communication between regions of the brain that are likely involved in auditory hallucinations and psychosis, suggesting it may be a potential drug target for alternative therapeutic strategies

In people with post-traumatic stress disorder (PTSD), fear-associated brain circuits overreact to cues that are similar to—but not the same as—features of a past traumatic experience. For example,… Read More

Researchers Trace Anxiety Control to Specific Brain Region

In animal research reported in the November 12 issue of the journal Nature, scientists have identified a specific region of the brain that helps regulate behaviors and physiological changes… Read More

New Insight About Why Mild Stress Can Trigger Extreme Responses in PTSD and Other Disorders

Researchers have uncovered new details about what happens in the brain when a mild source of stress generates an extreme response, disproportionate to the stress. Their findings identify possible… Read More

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