Brain Matters
Blog

Lynnette Averill, Ph.D., a clinical psychologist affiliated with the Baylor College of Medicine, Yale University, and the Department of Veterans Affairs, studies the causes and consequences of trauma-related psychopathology and suicidality, and is investigating novel rapid-acting interventions. She explains her special interest in the role that ketamine and psychedelics (including psilocybin and MDMA) could play treating veterans and others with severe PTSD who are at high risk for suicidal thoughts and behaviors.

Research on COVID’s impacts indicates how the pandemic is affecting families and child mental health, as well as how racial and socioeconomic factors can exacerbate risk and pose obstacles to care for those who are underserved by the healthcare system.

In an in-depth Q&A, Dr. David Miklowtiz, one of the world’s leading clinical authorities on treating bipolar disorder, offers a wealth information about this complexdisorder, including its range of manifestations. He also addresses the signs parents should pay attention to if they are concerned that their adolescent may have bipolar disorder; how to distinguish unipolar depression from depression that occurs in bipolar disorder; and how family-focused therapy can help patients and families reach better outcomes.

We offer A RESEARCHER’S PERSPECTIVE, based on a presentation given by Lisa M. Monteggia, Ph.D., of Vanderbilt University, at a zoom event hosted by BBRF. The topic of her presentation was “Studying Ketamine’s Rapid Effects to Unlock Secrets for Developing Better Antidepressants.” Dr. Monteggia reflects on what she has learned about antidepressant mechanisms from the therapeutic results obtained with the experimental drug ketamine.

Our PATHWAYS TO THE FUTURE story is about an unconventional approach to developing new psychiatric drugs. Based on an initiative by the National Institute of Mental Health, it’s called “Fast-Fail” and is designed to weed out the weakest drug candidates early in the process, to save time and money. In its first comprehensive test, a team led by two BBRF grantees and including 11 other BBRF grantees, Scientific Council members and prize winners, demonstrated the approach using a potential drug to treat anhedonia—the inability to experience or seek pleasure—which is seen in a number of psychiatric disorders including depression, anxiety, and PTSD.