Dr. Fan’s research focuses on understanding overlapping brain circuitry underlying mood, sleep, and epilepsy, and on advancing personalized neuromodulation strategies for psychiatric and neurologic disorders. Her work investigates how deep-brain networks regulate mood, arousal, and pathological excitability. Utilizing intracranial recordings from an ongoing clinical trial at UCSF involving individuals with treatment-resistant depression, Dr. Fan has demonstrated that corticolimbic and arousal networks are interconnected and that targeted stimulation of these circuits can modulate both mood and wakefulness. Her studies have helped identify neural biomarkers that may guide more personalized therapeutic interventions. More recently, she has advanced the use of low-intensity focused ultrasound as a non-invasive tool for stimulation mapping and modulation of deep brain networks involved in mood and related symptoms.