The overarching aim of Dr. Fernandez-Ruiz's research is to understand how neuronal dynamics in distributed brain circuits support complex cognitive functions and how small imbalances can lead to pathological states. This process is supported by the fine-tuned coordination of different neuronal populations in distributed brain circuits. A major obstacle to answering this question is limitations imposed by current technology; thus, the lab seeks to develop new methods for a more precise interrogation and manipulation of brain circuit dynamics in behaving animals.

Specifically, Dr. Fernandez-Ruiz is investigating the computations and underlying cellular mechanisms that support the role of hippocampo-cortical interactions in learning, memory, and decision-making during normal and pathological states. His team tackles these questions by developing and applying cutting-edge experimental and analytical techniques in rodents. They investigate alterations in hippocampal and cortical circuit dynamics underlying memory deficits in genetic mouse models of Alzheimer's disease and schizophrenia. They seek to develop novel intervention strategies, such as closed-loop optogenetic manipulations of neural dynamics, to reverse pathological memory deficits.