Probing and Rescuing Dysfunctional Brain Circuits in Depression

Tuesday, April 14, 2026, 2:00 pm EDT
Probing and Rescuing Dysfunctional Brain Circuits in Depression

Depression is a fundamentally episodic psychiatric disorder, but the mechanisms that drive mood-state transitions over time are not well understood. Dr. Liston will present findings from a series of parallel studies in preclinical mouse models and in patients with depression aimed at developing new treatment approaches by identifying the cellular and circuit-level mechanisms that initiate and sustain mood-state switches.

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Presented by 
Conor Liston, M.D., Ph.D.
Conor Liston, M.D., Ph.D.

Professor of Psychiatry

Professor of Developmental Psychobiology

Professor of Neuroscience

Weill Cornell Medical College

Scientific Council Member (Joined 2025)

2013 Young Investigator Grant

 

Conor Liston, M.D., Ph.D., is a Professor of Neuroscience and Psychiatry at Weill Cornell Medicine. The long-term goals of his research are to define basic mechanisms by which prefrontal cortical brain circuits support learning, memory, and motivation, and to understand how these functions are disrupted in depression, OCD, and other neuropsychiatric disorders. His team is also developing neuroimaging technologies for informing psychiatric diagnosis in human populations and predicting treatment response to transcranial magnetic stimulation and other forms of therapeutic neuromodulation.

He graduated summa cum laude from Harvard College in 2002, and received his PhD and MD from The Rockefeller University and Weill Cornell Medicine in 2007 and 2008, respectively. He subsequently completed his residency in psychiatry at NewYork–Presbyterian Hospital and postdoctoral training at Stanford University. He returned to Weill Cornell as an Assistant Professor in 2014. His research has been recognized with awards from the Klingenstein-Simons Foundation Fund, the Rita Allen Foundation, the Dana Foundation, the One Mind Institute, the Pritzker Neuropsychiatric Disorders Consortium, the Hope for Depression Research Foundation, the Wellcome Leap Foundation, the Jeanne and Herbert Siegel Award for Outstanding Medical Research, the Thomas W. Salmon Award from the New York Academy of Medicine, and the Eva King Killam Award from the American College of Neuropsychopharmacology. He is also a clinically active psychiatrist specializing in the management of treatment-resistant mood disorders.

Moderated by
Jeffrey Borenstein, M.D.
Brain & Behavior Research Foundation
 

Jeffrey Borenstein, M.D., serves as the President & CEO of the Brain & Behavior Research Foundation, the largest private funder of mental health research grants. Dr. Borenstein developed the Emmy-nominated public television program “Healthy Minds,” and serves as host and executive producer of the series. The program, broadcast nationwide, is available online, and focuses on topics in psychiatry in order to educate the public, reduce stigma and offer a message of hope. Dr. Borenstein served as Editor-in-Chief of Psychiatric News, the newspaper of the American Psychiatric Association from 2012 - 2023.

Dr. Borenstein is a Fellow of the New York Academy of Medicine and serves as the Chair of the Section of Psychiatry at the Academy. He also has served as the President of the New York State Psychiatric Association. Dr. Borenstein earned his undergraduate degree at Harvard and his medical degree at New York University.