Ian Maze, Ph.D.
2014 Young Investigator Grant
Ian Maze, Ph.D.
Howard Hughes Medical Institute Investigator
Professor, Neuroscience Professor
Professor, Pharmacological Sciences
The Maze laboratory is focused on understanding the complex interplay between chromatin regulatory mechanisms in brain and neuronal plasticity. We combine a wide variety of biochemical, biophysical, molecular and behavioral approaches to assess the role of histone proteins, and their associated posttranslational modifications, turnover dynamics and remodeling activities, in the regulation of normal neurodevelopment, and the contribution of such processes, or aberrations thereof, to neurological and psychiatric disease. We place particular emphasis on psychiatric disorders associated with monoaminergic (e.g., serotonin, dopamine, etc.) dysfunction, such as major depressive disorder and drug addiction, as well as neurodevelopmental syndromes resulting in deficits in synaptic plasticity and intellectual disability (e.g., Down syndrome and autism). Being both ‘basic’ and translational in nature, our work – so-called “mechanistic neuroepigenetics” – employs state-of-the-art gene and chromatin arraying technologies, analytical chemistry (e.g., mass spectrometry and 14C bomb pulse labeling) and neurobiological phenotyping, in both rodents and humans (postmortem brain and iPSC derived neurons), to explore novel chromatin phenomena in the central nervous system. This includes the identification and characterization of neuronally enriched histone modifications, chromatin “readers,” “writers” and “erasers,” all of which play critical roles in neuronal plasticity and behavioral adaptation.
Learn More About the Foundation
The Brain & Behavior Research Foundation is a global nonprofit organization focused on improving the understanding, prevention and treatment of psychiatric and mental illnesses.
Beginning in 1987, the Brain & Behavior Research Foundation was providing seed money to neuroscientists to invest in “out of the box” research that the government and other sources were unwilling to fund. Today, Brain & Behavior Research Foundation is still the leading, private philanthropy in the world in this space.
Meet the people who make up the Brain & Behavior Research Foundation. Our staff of experts, passionate Board of Directors, and Scientific Council which includes Nobel prize winners and chairs of psychiatric departments around the world.
We take our responsibility to our donors seriously and believe that our financial operations must be transparent. We're proud to say that 100% of your contribution for research is invested directly in research grants.