Dr. Zhou lead and participated in several innovative projects and got interesting findings: demonstrated the shared genetic susceptibility contributes to alcohol dependence (AD) and major depression (MD); detected the first gene for the AD-MD comorbidity by genome-wide association study (GWAS); accomplished the largest to date GWAS for alcohol consumption and alcohol use disorder in the Million Veteran Program (MVP); detected a glutamate ionotropic receptor gene as risk for comorbid nicotine dependence and MD. His ongoing projects are focus on: 1). understanding the genetic etiology of opioid use disorder by analyzing MVP data; 2). large scale whole exome sequencing to identify genetic risks for comorbid MD and substance use; 3). shared and causal mechanism between alcohol consumption and MD; 4). causal relationship between alcohol consumption and cancers.