Brain & Behavior Magazine presents the cutting edge research of our BBRF grantees. This issue focuses on developing new technologies to stimulate the brain, what we don't know about using psychedelics to treat mental illness, and what large-scale genetics research is revealing about the biology underlying substance abuse disorders.

A RESEARCHER’S PERSPECTIVE: What Genetics Is Telling Us About Substance Use Disorders

Posted: January 28, 2024

Dr. Sandra Sanchez-Roige explains how large-scale studies of genome variations have identified risk locations for substance use disorders. She also discusses the importance of converting these signals from the genome into biological understanding of mechanisms and vulnerabilities which may provide a path forward for the development of novel treatments.

On Fentanyl, the Opioid Crisis, Psychedelics, and Cannabis Risk: A Q&A with Dr. Nora Volkow

Posted: January 28, 2024

Dr. Volkow, Director of the National Institute on Drug Abuse (NIDA) and leading authority on substance use and the science of addiction, explains the origins of the fentanyl crisis, the challenges of treating overdoses, and offers her assessment of psychedelics as therapies for psychiatric illness, as well as current evidence on the dangers of regular cannabis use among young people.

ECT, MST, and Other Neuromodulation Therapies to Relieve Severe Psychiatric Illness

Posted: January 28, 2024

Dr. Sarah Lisanby has been deeply involved in developing and improving the safety of life-saving neuromodulatory treatments including electroconvulsive therapy (ECT) and magnetic seizure therapy (MST) for severe psychiatric illness.

Small Preliminary Trial of Psychoactive Drug Ibogaine Yields ‘Initial Evidence’ for Powerful Therapeutic Potential in Traumatic Brain Injury

In an exploratory and preliminary clinical test, a team of researchers at Stanford University has obtained “initial evidence” suggesting that a psychoactive compound called ibogaine, when co-administered with magnesium, “could be a powerful therapeutic” to safely treat a variety of psychiatric symptoms, including PTSD, major depression and anxiety, and suicidality, all of which may e

New, Potential First-in-Class Schizophrenia Medicine Reduced Positive and Negative Symptoms in Phase 3 Trial

A new medicine for treating schizophrenia—one that appears to help reduce both positive and negative symptoms of the illness—has passed a first hurdle in phase 3 clinical testing. Phase 3 is often pivotal in deciding whether a medicine is effective and safe enough to obtain FDA approval.  

Zhi-De Deng, Ph.D.

Zhi-De Deng, Ph.D.
Position

Director of the Computational Neurostimulation Research Program, Noninvasive Neuromodulation Unit

University

National Institute of Mental Health

Position

Assistant Professor, Psychiatry & Behavioral Sciences

University

Duke University School of Medicine

Grant or Prize

2017 Young Investigator Grant

Dr. Deng is Director of the Computational Neurostimulation Research Program, Noninvasive Neuromodulation Unit, at the National Institute of Mental Health. He is also Adjunct Assistant Professor of Psychiatry & Behavioral Sciences, Duke University School of Medicine. He received the SB degree in physics, SB and MEng in electrical engineering and computer science, with a minor in economics, from MIT. He received PhD and MPhil in electrical engineering, with a graduate minor in neuroscience, from Columbia University. He completed postdoctoral training at Duke and research fellowship at NIMH.

In Trial, Magnetic Seizure Therapy (MST) Was Just as Effective as Electroconvulsive Therapy (ECT) in Treating Severe Depression, and Likely Safer

In a new paper, researchers have reported results of the largest double-blind, randomized clinical trial to date comparing the effectiveness and safety of two important therapies for severe and treatment-resistant depression: electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). Both were highly effective, although they differed in some potentially important respects.

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