An Update on Treatment of Bipolar Depression

Tuesday, August 11, 2020
An Update on Treatment of Bipolar Depression

Bipolar depressive episodes are the main burden for people with bipolar disorder. People with a history of mania experience bipolar depressive episodes or symptoms about a third of the time, while those with a history of hypomania can experience them more than half the time. Antidepressants in general have not been shown to be better than placebo, yet they remain the most common treatments. Dr. Nierenberg will review other existing and potential treatments, including ECT; non-invasive brain stimulation (rTMS); ketamine and esketamine; lamotrigine; and cognitive behavioral therapy and family-focused therapy.

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Presented by 
Andrew A. Nierenberg, M.D.
Andrew A. Nierenberg, M.D.

Thomas P. Hackett, MD Endowed Chair in Psychiatry

Massachusetts General Hospital

Professor of Psychiatry

Harvard Medical School

Scientific Council Member (Joined 2010)

2013 Colvin Prize for Outstanding Achievement in Mood Disorders Research

2013 Distinguished Investigator Grant

2003, 2000 Independent Investigator Grant


Dr. Nierenberg’s primary research interests are treatment resistant depression, bipolar depression, and the longitudinal course of mood disorders. He also maintains an active clinical practice and conducts clinical trials. He has been listed among the Best Doctors in North America for the treatment of mood and anxiety disorders continuously since 1994.

Dr. Nierenberg attended the Albert Einstein College of Medicine of Yeshiva University followed by a residency in psychiatry at New York University/Bellevue Hospital and then became a Robert Wood Johnson Clinical Scholar at Yale University. In 1992, he joined the Psychiatry Department at MGH. He lectures nationally and internationally and teaches and supervises both clinicians and researchers.

Moderated by 
Jeffrey Borenstein, M.D.
Brain & Behavior Research Foundation

President and CEO


Jeffrey Borenstein, M.D., serves as the President & CEO of the Brain & Behavior Research Foundation, the largest private funder of mental health research grants. Dr. Borenstein developed the Emmy-nominated public television program “Healthy Minds,” and serves as host and executive producer of the series. The program, broadcast nationwide, is available online, and focuses on topics in psychiatry in order to educate the public, reduce stigma and offer a message of hope. Dr. Borenstein also serves as Editor-in-Chief of Psychiatric News, the newspaper of the American Psychiatric Association.

Dr. Borenstein is a Fellow of the New York Academy of Medicine and serves as the Chair of the Section of Psychiatry at the Academy. He also has served as the President of the New York State Psychiatric Association. Dr. Borenstein earned his undergraduate degree at Harvard and his medical degree at New York University.