Roland Zahn, M.D., Ph.D., King’s College London, will explore a potential new treatment for treatment-resistant depression. Dr. Zahn will test the efficacy of “neurofeedback” in patients who haven’t responded to treatment. This technique involves patients viewing their own brain activity as viewed through functional magnetic resonance imaging, and then using this activity as a guidepost for behaving differently to reduce their symptoms. The project will compare this technique against a psychological, thought-based training technique, to isolate any unique improvements from the neurofeedback not caused by purely psychological effects. If successful, these tests will support neurofeedback as a promising new treatment, especially for currently intractable depression.