Jessica Mariani, Ph.D.
BBRF Awards & Recognition
2016 NARSAD Young Investor Grantee
Jessica Mariani, Ph.D.
Title & Institution
BBRF Awards & Recognition
Bio
Jessica Mariani, Ph.D., Yale University, will explore how changes in the 3D organization of DNA can alter gene expression and neurodevelopment, leading to autism spectrum disorders. Dr. Mariani will construct a 3D map of DNA interactions in ASD patients and their unaffected fathers using so called brain organoids. These findings will reveal how changes in DNA organization can orchestrate the disruption of molecular pathways implicated in neuropsychiatric disorders, and may provide new targets for therapeutic strategies.
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