Schizophrenia

Did you know that schizophrenia affects more than 1 percent of the world's population? See NARSAD Grants at work on the latest schizophrenia research

Schizophrenia is a severe, chronic, and generally disabling brain and behavior disorder. It is most accurately described as a psychosis - a type of illness that causes severe mental disturbances that disrupt normal thoughts, speech, and behavior. Schizophrenia is believed to be caused by a combination of genetic and environmental factors.

Positive symptoms may include delusions, thought disorders, and hallucinations. People with schizophrenia may hear voices other people don't hear, or believe other people are reading their minds, controlling their thoughts, or plotting to harm them. Negative symptoms may include avolition (a lack of desire or motivation to accomplish goals), lack of desire to form social relationships, and blunted affect and emotion. Cognitive symptoms involve problems with attention and memory, especially in planning and organization to achieve a goal. Cognitive deficits are the most disabling for patients trying to lead a normal life.

Schizohrenia research & FAQs


Visit the Schizophrenia Research Forum, fully sponsored by the Brain & Behavior Research Foundation—a virtual community of scientists collaborating in their quest for causes, improved treatments, and better understanding of schizophrenia.

Visit the Schizophrenia Research Forum for more information about research

Bryan L. Roth, M.D., Ph.D
Bryan L. Roth, M.D., Ph.D
February 01, 2011

Bryan L. Roth, M.D., Ph.D., NARSAD Scientific Council member, is a well known expert on psychopharmacology. In recent years, he has developed several experimental technologies that are now paying dividends in research...

Jonathan Javitch, M.D., Ph.D., of Columbia University
Jonathan Javitch, M.D., Ph.D.
February 01, 2011

NARSAD Scientific Council member Jonathan Javitch, M.D., Ph.D., of Columbia University, is part of a team that recently determined the structure of one of the five dopamine receptors in the human brain — the culmination...

Marcia, Sean and Paul Garatt - a family battling schizophrenia, depression and anxiety
The Garatt Family
February 01, 2011

No one knows better than the Garatt family how far research in mental illness has come – and how far it still has to go. Thirty-three years ago, when Sean Garatt was diagnosed with schizophrenia, his mother, Marcia, was...

Jonathan Javitch, M.D., Ph.D.
Dr. Jonathan Javitch
February 01, 2011

Expressed widely throughout the brain, dopamine is a message-carrying molecule called a neurotransmitter, which is involved in a number of regulatory processes related to movement and aspects of cognition such as...

Brain & Behavior Research Foundation
January 03, 2011

NARSAD Independent Investigator Andrew McIntosh, in the culmination of 10 years of work, finds that the brains of people who later develop schizophrenia suffer from an accelerated shrinking before the onset of illness....

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