ketamine

Following Ketamine with Daily Buprenorphine for 1 Month Led to Continued Declines in Suicidal Ideation in Patients Treated for Major Depression
A research team led by BBRF grantees has reported the first randomized, controlled trial in patients with major depressive disorder (MDD) to demonstrate that a pharmacological intervention—follow-on… Read More
Experiments That May Answer the Riddle of Ketamine’s Rapid Antidepressant Action Are Basis for Finding Other Rapid-Acting Treatments With Fewer Side Effects
In a what could be a major step forward in depression research, a team led by BBRF grantees has reported the results of experiments that they say reveals the mechanism through which the rapid anti-… Read More
Direct Evidence of Ketamine’s Antidepressant Action in Imaging Study of Excitatory Neuronal Receptors
A team of researchers has published results of experiments in patients with treatment-resistant depression that provides direct evidence of at least one important mechanism through which ketamine… Read More
Researchers Trace How Ketamine Acts on Specific Brain Circuits and Synapses to Relieve Anhedonia
Researchers have published a highly detailed account of a mechanism through which ketamine, a rapid-acting antidepressant, alters plasticity, or the strength of connections between neurons, and in so… Read More
Novel Target in Dopamine Neurons is Basis of Potential New Therapeutic Approach for Treatment-Resistant Depression
Even with the development and FDA approval in recent years of the first rapid-acting antidepressant medicines—to which more than 90 BBRF grants have contributed—the search for novel depression… Read More