My sister lives with depression and seems to be having increasing issues with her memory as well. You say that stress and depression can “shrink” the brain. Can antidepressants and/or other treatments reverse that?

Printer-friendly versionPrinter-friendly version
Bruce S. McEwen, Ph.D. - Brain and behavior research expert on depression

Chronic depression is associated with shrinkage of brain areas that are involved in memory. Regular physical activity, such as walking an hour a day, enlarges these brain areas and improves function––probably the best antidepressant of all!

Bruce S. McEwen, Ph.D.
Alfred E. Mirsky Professor, The Rockefeller University
1998 NARSAD Distinguished Investigator Grant
2005 Goldman-Rakic Prize for Outstanding Achievement in Cognitive Neuroscience
Foundation Scientific Council Member