John H. Krystal, M.D.

John H. Krystal, M.D.


Robert L. McNeil Jr. Professor of Translational Research
Chair, Department of Psychiatry
Chief of Psychiatry, Yale-New Haven Hospital
Director, National Institute on Alcohol Abuse and Alcoholism Center for the Translational Neuroscience of Alcoholism
Director, Clinical Neuroscience Division, VA National Center for PTSD
Director, VA Alcohol Research Center
Medical Director, Schizophrenia Biological Research Center, DVA

Dr. Krystal is an expert on the neurobiology and treatment of schizophrenia, post-traumatic stress disorder and alcoholism. In these areas, he has linked experimental psychopharmacology, neuroimaging and genetics to identify disturbances in the function of brain circuits, particularly those involving glutamate and GABA that might be targeted in the development of new treatments. He developed the use of ketamine as a probe of glutamate receptor function in brain and behavior disorders. This work contributed to the development of mGluR2/3 agonist treatments for schizophrenia and riluzole and NMDA receptor antagonist treatments for depression and alcoholism.

Dr. Krystal is the current President of the American College of Neuropsychopharmacology.

NARSAD Grants: Independent Investigator 1997, Distinguished Investigator 2000 and 2006