Jacqueline N. Crawley, Ph.D.

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Jacqueline N. Crawley, Ph.D.


Robert E. Chason Chair in Translational Research, MIND Institute
Professor, Department of Psychiatry and Behavioral Sciences
University of California Davis School of Medicine, Sacramento

Dr. Crawley’s laboratory focuses on the development and translational application of mouse models of autism spectrum disorder (ASD) to test hypotheses about how autism develops and to evaluate potential pharmacological treatments. As candidate genes associated with ASD are identified, mice with targeted mutations in these genes are worked with. Model organisms offer useful translational tools to test hypotheses about single genes, chromosomal locus deletions, copy number variants, methylation and other epigenetic mechanisms (environmentallyinduced changes in gene regulation), neuroanatomical abnormalities, environmental toxins, diets, immune dysfunctions and other proposed causes of autism. Her laboratory team is evaluating pharmacological interventions like mGluR5 and AMPA receptor modulators for therapeutic improvements in the social, communication and repetitive behavior domains in mouse models.

Before joining UC Davis, Dr. Crawley was the Chief of Laboratory of Behavioral Neuroscience at the Intramural Research Program at the NIMH.