Eric J. Nestler, M.D., Ph.D.

Eric J. Nestler, M.D., Ph.D.


Nash Family Professor
Chair, Department of Neuroscience
Director, Friedman Brain Institute
Icahn School of Medicine at Mount Sinai

Dr. Nestler studies the molecular basis of addiction and depression in animal models, focusing on the brain pathways that regulate responses to natural rewards such as food, sex and social interaction. His research has established that drug- and stress-induced changes in genetic transcription factors and chromatin remodeling mechanisms in reward pathways mediate long-lived behavioral changes relevant to addiction and depression.

Before moving to Mount Sinai, Dr. Nestler was Chair of Psychiatry at the University of Texas Southwestern Medical Center at Dallas and the Director of the Abraham Ribicoff Research Facilities and the Division of Molecular Psychiatry at Yale.

NARSAD Grants: Distinguished Investigator 1996

Foundation Prizes: 2008 Goldman-Rakic Prize for Outstanding Achievement in Cognitive Neuroscience Research and the 2009 Falcone Prize for Outstanding Achievement in Affective Disorders Research (renamed the Colvin Prize in 2012)