Dennis L. Murphy, M.D.

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Dennis L. Murphy, M.D.


Chief, Laboratory of Clinical Science
National Institute of Mental Health Intramural
Research Program

Dr. Murphy’s laboratory explores the neurobiology of brain and behavior disorders using molecular, neurochemical and genetic techniques. Genetically engineered mice provide a basis for the lab’s investigations of brain disorders such as obsessive-compulsive disorder (OCD) and depression. The serotonin neurotransmitter system and several of its key molecules, including the serotonin transporter (SERT) and serotonin receptors and enzymes—the target molecules for the majority of neuropsychiatric medications—are the primary targets of Dr. Murphy’s research. So-called SERT knock-out mice provide Dr. Murphy’s lab with a powerful tool with which to investigate what the serotonin system does in living creatures.

Dr. Murphy received his undergraduate degree from Marquette University, his medical degree and master of science degrees from the Medical College of Wisconsin. He completed his internship and residency programs at the University of Minnesota and Johns Hopkins University.