NARSAD Young Investigator Grantee Andrea Danese, MD, PhD, and Colleagues, Discover Childhood Abuse Victims Twice as Likely to Suffer Depression and Respond Poorly to Treatments

The biological abnormalities associated with childhood abuse could explain why some people respond poorly to treatment for depression.

External factors like abuse (as opposed to internal genetic factors) can cause certain biological abnormalities to the brain, endocrine and immune systems ─ indicating that environment can alter the way genes are expressed. These findings open the door promising additional research for new treatments.

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