Acetylcholine Receptors can be activated by Acetylcholine in both ways on binding and releasing from AchR. Artificial disrupting Acetylcholine activities acting to AchR, would disrupt human emotion balance. Have you seen when the Olympic sporters are extremely too happy to cry but unable to laugh when they are received the award for golden plates to their winedon the top of the first games in Olympic campaigning? This is a typical instance of when large amount of Acetylcholine are binding on AchR to cause caused too much activations of mAchR on activating releasing Acetylcholine to feedback suppressing AchR activities. Only at this point, AchE hydrolysis Acetylcholine from binding of AchR could moderately down the sportor’s emotions.