Breakthrough in Schizophrenia Research by Foundation's 2011 Outstanding Prizewinner

Joel E. Kleinman, M.D., Ph.D.
Joel E. Kleinman, M.D., Ph.D.

Joel E. Kleinman, M.D., Ph.D., the Foundation’s 2011 Lieber Prizewinner for Schizophrenia Research, led groundbreaking research which involved, for the first time, mapping brain development across different stages of life by changes in gene expression. The results of these studies, which involved the analysis of post-mortem brain tissue, were published in the October 26, 2011 issue of Nature Magazine. The findings shed light on the pathology and risk factors for severe mental illnesses like schizophrenia. “Ultimately, we want to find targets for treatment; this lets you take the first step in understanding how genetic variants increase risk for any brain disease,” Kleinman said.

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Watch Dr. Kleinman's Outstanding Achievement Prize Video:


Article comments

As a layman i have been hearing about breakthrough in Schizophrenia research. Except for Clozapine drug therapy, I find none of them are making it to the welfare and better life for Schizophrenics.

What roles do pituatary and/or pineal glands play in psychosis, (if any)? Have researchers considered these glands in any way for hallucinations/delusions? Ancient texts & metaphysical books mention these two glands and an imbalance within them. If insurance companies now pay for accupuncture, meditation & yoga -- all which are thousands of yrs. old & previously labeled "whoo hoo" nonsense by the medical community-- why not check out the ancient texts on "chakra" points in the brain: both which correspond to pineal and pituatary glands. Supposedly, when these "chakra" points are inbalanced, then hallucinations/delusions happen.

are these questions answered or are they just up here to make the site look interactive?

Hi Cherly,

If you would like to ask a question, please visit our "Ask an Expert" section. The comment section beneath articles is just for people to react to the article or have conversations with other readers.

Thanks for your support,

Your friends at the Brain & Behavior Research Foundation

i definately believe the pituatary has something to do with it my son has been having some issues and his fsh level has been low but they say that its not that bad but i think is is the cause of a lost of confusion with him,,,, and accupuncture works...... it has helped him a lot i dont believe he is schizophenic..... i think is due to heavy medals in the body due to poor diet,, toxins in the body....i will figue this out...........

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