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Did you know that schizophrenia affects more than 1 percent of the world's population? See NARSAD Grants at work on the latest schizophrenia research

Schizophrenia is a severe, chronic, and generally disabling brain and behavior disorder. It is most accurately described as a psychosis - a type of illness that causes severe mental disturbances that disrupt normal thoughts, speech, and behavior. Schizophrenia is believed to be caused by a combination of genetic and environmental factors.

Positive symptoms may include delusions, thought disorders, and hallucinations. People with schizophrenia may hear voices other people don't hear, or believe other people are reading their minds, controlling their thoughts, or plotting to harm them. Negative symptoms may include avolition (a lack of desire or motivation to accomplish goals), lack of desire to form social relationships, and blunted affect and emotion. Cognitive symptoms involve problems with attention and memory, especially in planning and organization to achieve a goal. Cognitive deficits are the most disabling for patients trying to lead a normal life.

Schizohrenia research & FAQs


Visit the Schizophrenia Research Forum, fully sponsored by the Brain & Behavior Research Foundation—a virtual community of scientists collaborating in their quest for causes, improved treatments, and better understanding of schizophrenia.

Visit the Schizophrenia Research Forum for more information about research

Husseini K. Manji, M.D. of Duke University
Husseini K. Manji, M.D.
August 26, 2011

Brain & Behavior Research Foundation Scientific Council Member, Dr. Husseini Manji, is one of the leading contemporary explorers of the brain ─ that remarkable 3-pound organ which he reminds us is “the very basis of...

Lori Altshuler, M.D.
Lori Altshuler, M.D.
August 26, 2011

Bipolar disorder is characterized by cycles of mania and depression. Although the manic state is more dramatic, the depressed state is experienced three times more frequently.  A number of medications and modalities are...

Hongjun Song, Ph.D., Johns Hopkins University School of Medicine, Expert on Brain Research and Autism
Hongjun Song, Ph.D.
August 26, 2011

The adult mammalian brain can generate new cells, an ability crucial to healthy brain functioning but one that can be compromised by aging or illness. In the June 24 issue of the journal Cell, Brain & Behavior...

Anthony J. Rothschild, M.D., University of Massachusetts
Anthony J. Rothschild, M.D.
August 26, 2011

Psychotic depression, which is major depressive disorder combined with psychotic delusions or hallucinations, often goes undiagnosed. The kinds of delusions that tend to typify this condition often involve fears, such as...

Guy A. Rouleau, M.D., Ph.D., University of Montreal Hospital
Guy A. Rouleau, M.D., Ph.D.
August 26, 2011

Many studies have shown that schizophrenia is a highly heritable disorder; that it is largely triggered by inherited genetic mutations or abnormal changes in the composition and function of genes. But genetic errors...

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