Dennis S. Charney, M.D.

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Dennis S. Charney, M.D.

JOINED THE SCIENTIFIC COUNCIL IN 1999

Anne and Joel Ehrenkranz Dean of Icahn School of Medicine at Mount Sinai
Executive Vice President for Academic Affairs,
The Mount Sinai Medical Center

Dr. Charney studies the neurobiology and treatment of mood and anxiety disorders. His investigations have yielded fundamental contributions to the understanding of neural circuits, neurochemistry and functional neuroanatomy of the regulation of mood and anxiety and the psychobiological mechanisms of human resilience to stress. He led a team who determined that the biology of human anxiety disorders was characterized by excessive noradrenergic activity and dysfunction in specific neural circuits, including the prefrontal cortex, amygdala, and hippocampus. His work in depression led to new hypotheses regarding the mechanisms of antidepressant drugs and the discovery of novel therapies for treatmentresistant depression, such as lithium and ketamine, which have been shown to work within hours.

From 2000 to 2004, Dr. Charney was Chief of the Mood and Anxiety Disorders Research Program and the Experimental Therapeutics and Pathophysiology Branch at the NIMH. Prior to that, he was Professor of Psychiatry and Deputy Chair of Academic and Scientific Affairs at the Yale University School of Medicine. He was the Principal Investigator of the Veterans Administration National Center for Post-Traumatic Stress Disorder and the NIMH Yale Mental Health Clinical Research Center.

NARSAD Grants: Distinguished Investigator 2007