Schizophrenia

Did you know that schizophrenia affects more than 1 percent of the world's population? See NARSAD Grants at work on the latest schizophrenia research

Schizophrenia is a severe, chronic, and generally disabling brain and behavior disorder. It is most accurately described as a psychosis - a type of illness that causes severe mental disturbances that disrupt normal thoughts, speech, and behavior. Schizophrenia is believed to be caused by a combination of genetic and environmental factors.

Positive symptoms may include delusions, thought disorders, and hallucinations. People with schizophrenia may hear voices other people don't hear, or believe other people are reading their minds, controlling their thoughts, or plotting to harm them. Negative symptoms may include avolition (a lack of desire or motivation to accomplish goals), lack of desire to form social relationships, and blunted affect and emotion. Cognitive symptoms involve problems with attention and memory, especially in planning and organization to achieve a goal. Cognitive deficits are the most disabling for patients trying to lead a normal life.

Schizohrenia research & FAQs


Visit the Schizophrenia Research Forum, fully sponsored by the Brain & Behavior Research Foundation—a virtual community of scientists collaborating in their quest for causes, improved treatments, and better understanding of schizophrenia.

Visit the Schizophrenia Research Forum for more information about research

Jennifer Gottlieb, Ph.D., NARSAD YI, Dartmouth Medical School
Jennifer Gottlieb, Ph.D.
November 15, 2011

Upwards of half of people taking antipsychotic medications continue to have some symptoms of psychosis. Cognitive behavioral therapy (CBT) is a non-pharmaceutical intervention that helps people develop skills for coping...

Pablo Gejman, M.D.
Pablo Gejman, M.D.
November 15, 2011

Genome-wide association studies (GWAS), begun in 2005 as a coordinated international effort to search for genes associated with susceptibility for complex diseases, have yielded important findings in virtually every major...

Stephen Maguire
Stephen Maguire
November 15, 2011

Stephen Maguire, a doctoral student in mathematics at the University of Illinois at Urbana Champaign, began noticing a while back that sometimes on his way home from class the streets would seem unnaturally empty. A...

Joel E. Kleinman, M.D., Ph.D.
Joel E. Kleinman, M.D., Ph.D.
November 09, 2011

Joel E. Kleinman, M.D., Ph.D., the Foundation’s 2011 Lieber Prizewinner for Schizophrenia Research, led groundbreaking research which involved, for the first time, mapping brain development across different stages of life...

Fred H. Gage, Ph.D.
Fred H. Gage, Ph.D.
November 03, 2011

Led by Fred H. Gage, Ph.D., investigators are carefully investigating these newly formed brain cells to learn what can go awry in brain development to cause illnesses such as schizophrenia and autism. By recreating these...

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