Foundation-Funded Discovery: Patients Can Have Full Relief of Depression by Using Regular Exercise as Second ‘Medication’

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Madhukar H. Trivedi, MD
Madhukar H. Trivedi, MD

NARSAD Independent Investigator Madhukar H. Trivedi, MD and colleagues have discovered that various forms of exercise worked as effectively as adding a second antidepressant medication.

The 4-year controlled study involved patients performing various forms of exercise, journaling and meeting regularly with a psychiatrist. The results demonstrated that medication combined with a regular exercise routine fully relieved the symptoms of major depressive disorder for up to 50% of patients requiring more than one antidepressant.

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Been studying the mood altering effects of regularly bicycling for over a decade. When several days intervene (bad weather, other distractions), depressed feelings set in. During activity, brain activity of all types increases dramatically, but, shortly after physical exhaustion, crash. However, mood seems incrementally improved as long a repetition is frequent enough. Reliance on automotive convenience depresses.

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