Scientific Council Member Leads Team in Discovery of Mechanism that Links Substance Abuse with Susceptibility to Depression

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Eric J. Nestler, MD, PhD
Eric J. Nestler, MD, PhD

While most studies focus on brain and behavior disorders as cause for substance abuse (ie., self-medication), Scientific Council Member Eric Nestler, M.D., Ph.D. and colleagues have discovered how substance abuse can actually increase risk for stress-related illness. “Our results provide fundamentally novel insight into how prior exposure to a drug of abuse enhances vulnerability to depression and other stress-related disorders,” says Dr. Nestler. “Identifying such common regulatory mechanisms may aid in the development of new therapies for addiction and depression.”

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