Gene Linked to Bipolar Disorder, Schizophrenia Plays Key Role in Brain Development

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Tracey L. Petryshen, Ph.D. - brain and behavior research expert on schizophrenia
Tracey L. Petryshen, Ph.D.

During brain development, the brain is a frenzy of activity: new brain cells (neurons) are born, migrate to where they need to go, and eventually form connections with other neurons. Subtle problems with any of these steps can change the brain’s wiring diagram, and contribute to risk for developing schizophrenia and other psychiatric diseases.

A study published online May 13th in Molecular Psychiatry links an abnormality in the birth of neurons to schizophrenia and bipolar disorder. Led by Li-Huei Tsai of the Massachusetts Institute of Technology, the study focused on the workings of ANK3, a gene implicated in both bipolar disorder and schizophrenia. Loss of ANK3, the researchers report, elevated the number of newborn neurons in the embryonic mouse brain.

This abnormal production of cells could be traced to a signaling pathway involved in brain development (and, interestingly, cancer—a disease of abnormal cell production). The researchers, including three NARSAD Grantees, Tracey L. Petryshen, Ph.D. (2014 NARSAD Independent Investigator Grantee), Karun K. Singh, Ph.D. (2013 NARSAD Young Investigator Grantee) and Pamela B. Sklar, M.D., Ph.D. (1995, 1998, 2006 NARSAD Grantee), could restore normal levels of neuron birth by boosting levels of another member of this pathway, called glycogen synthase kinase 3 (GSK3β).

The findings uncover a new role for ANK3, which encodes a protein better known for getting the channels essential for electrical signaling in the right places along the axon, which carries information between neurons. The new results suggest that ANK3 can fine-tune the number of new neurons born, and that perhaps producing too many or too few brain cells can contribute to risk for developing schizophrenia or bipolar disorder.

Read more about this research on the Schizophrenia Research Forum.

Read the abstract of this research paper.

Article comments

Interesting read. So bipolar and schizophrenia are almost akin to a type of brain cancer, Fascinating! Thank you for sharing!

yes our son developed schizophrenia (apparent symptoms) at 17 years, suffering later from depression not surprisingly considering the toll this illness inflicted on his quality of life; but most importantly in regards to the research above our son at twelve years complained of having too many thoughts, his mind racing with too much activity (like a storm) and he had problems concentrating and suffered form auditory processing which in time developed later into a full psychosis of hallucinations, voices and paranoia.

I do NOT agree that these things are anything like brain cancer. I predict in the future, they may find that highly spiritual people who practice and have been initiated with the help of others into being a shaman will find the same deficiency. They know SO little about the brain, less than the stars in the sky - keep on researching for sure - but I say spirituality needs to be brought in to all of this AND the ways of the heart. The heart is the wiser one.

My granddaughter has just been diagnosed with bipolar. It is heart breaking. she is also pregnant with her 2nd child. Everyday at 2pm I call her with words from God. He loves everyone so much. His love is unsearchable and forever lasting. I am trusting in the Lord for all the mothers and family going thru this. Amen.

I'm sorry to contradict someone's beliefs, but with all due respect, I want to tell everyone, as a Bipolar Spectrum sufferer, that focusing on God and religion is not advisable when speaking with your Bipolar Spectrum Disorder children, relatives or friends. Thinking about God naturally leads to thinking about death. And loved ones they have lost. People with BSD spend a lot of time fighting death compulsion and obsession. Constantly reminding them that God and passed loved ones only serves to make them yearn for the peace of death even more. It would be wiser in my opinion to focus on helping them find creative projects to keep them focused On life, and leave the
"death talk" alone for the most part. You really have to be sensitive and careful not to "trigger" more of such thoughts and especiAlly, help them with self-care and coping day to day. Constant focus on God, praying, and heaven is not very compassionate in this situation despite how much it may comfort you. It 's like putting a gun in their hand and helping them put it in their mouth.

Wow! So bipolar and schizophrenia can be related to cancer??

Does the role of glycogen synthase kinase 3 have any implications for future treatments of bipolar or schizophrenia?

I was first told I had bipolar when I was 13. I'm now 37yrs old now I have been in the hospital once and the rest of the time have been under a doctor's care. I firmly agree do all the research you want. I for one would be the first in line if there was a cure, BUT I NEVER started noticing any changes in my self until I started changing spirituality. I still live day to day wishing things were different but their not. I have accepted that. My family hasn't but I have.

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