2005 Breakthrough: Identification of Brain Signaling Mechanism Opens Pathway for Development of Novel Treatments for Mental Illness

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Francis S. Lee, M.D., Ph.D. - Brain & behavior research expert on mental illness
Francis S. Lee, M.D., Ph.D.

Francis S. Lee, M.D., Ph.D., of Weill Cornell Medical College, was the recipient of two NARSAD Young Investigator Grants (in 2002 and 2005) that supported research on growth factors called NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor), which support the birth and growth of new brain cells. Dr. Lee wanted to see if there were alternate ways to activate these growth factor receptors so as to identify novel targets for next generation therapies for a broad range of mental illnesses.

He identified a novel brain signaling pathway to transactivate the neurotrophin receptors with small molecules that promoted neuroprotective actions, such as neuronal cell survival and synaptic plasticity (via BDNF and NGF receptors). His findings opened novel lines of investigation for development of neurotrophin-based treatments for a wide number of neurological and neurodegenerative diseases.

Read the abstract for this research from the Journal of Neuroscience.

Read the abstract for this research from Cognitive, Affective & Behavioral Neuroscience.

Read the abstract for this research from Science.

Read "NARSAD Grantees at the Leading Edge: A Quarter-Century of Groundbreaking Discoveries about the Brain’s Plasticity" from The Quarterly, Fall, 2013 with an excerpt on Dr. Lee's more recent work.

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Please note that researchers cannot give specific recommendations or advice about treatment; diagnosis and treatment are complex and highly individualized processes that require comprehensive face-to- face assessment. Please visit our "Ask an Expert" section to see a list of Q & A with NARSAD Grantees.
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